| Clinical Research | |
| Principal Investigator | Title of Research Proposal |
| Abbas Jaber | A multicenter phase II randomized trial comparing Docetaxel in combination with Doxuribicin and Cyclophosphamide (TAC) versus Doxorubicin and Cyclophosphamide followed by Docetaxel (AC →T) as adjuvant treatment of operable breast cancer HER-2-neu negative with positive axillary lymph nodes (BCIRG005) |
| Abboud Miguel | Study of pathophysiology of stroke in sickle cell disease |
| Abchee Antoine | A multicenter , randomized, controlled, double-blind trial to investigate the clinical efficacy and tolerability of early treatment with simvastatin 40 mg daily for 30 days, followed by simvastatin 80 mg daily thereafter in tirofiban-treated acute coronary syndrome patients who have been randomized to receive enoxaparin or unfractionated heparin in conjunction with aspirin, and in optimally treated ST-elevation acute coronary syndrome patients. |
| Abchee Antoine | Assessment of metabolic and genetic risk factors for coronary artery disease in Lebanese patients undergoing cardiac catheterization |
| Abdelnoor Alex | Some genetic and immunologic aspects of psoriasis |
| Abouchacra Kim | Universal newborn hearing screening program-phase I: Establishment of an optimal screening protocol and follow-up procedure |
| Abu-Musa Antoine | Type and frequency of chromosomal aberrations in couples with primary infertility |
| Arayssi Thuraya | Treatment of Behcet's uveitis with Infliximab (TNF-a antagonist): a pilot study |
| Arayssi Thurayya | Compliance and health outcomes osteoporosis study of Evista |
| Arayssi, Thurayya | A randomized double-blind study to evaluate the safety and efficacy of etoricoxib 60 mg and diclofenac sodium 150 mg in patients with osteoarthritis of the knee and hip |
| Aswad Naji | Gracial acceptance and tolerability in Lebanese patients |
| Azar Sami | Randomized open label study to assess the post-meal glucose achieved with starlix 120ng before meals three times daily |
| Azar Sami | 12 week open label study to assess efficacy and safety of Lescol XL 80mg slow release formulation administered at bedtime in patients with hypercholesterolaemia or mixed dyslipidemia |
| Azar Sami | Hyperglycemia and its effect after acute myocardial infarction on cardiovascular outcomes in patients with type 2 diabetes (HEART2D) |
| Azar Sami | A randomized, double-blind, placebo-controlled, multicenter study to evaluate efficacy, safety and tolerability of Ezetimibe 10mg or placebo added to Simvastatin 10 or 20mg in attaining low density lipoprotein cholesterol target levels in patients with hypercholesterolemia and coronary heart disease |
| Balian Saucy | Infant morbidity and mortality related to timing of birth |
| Bitar Fadi | Children's Cardiac Registry Center |
| Bitar Fadi | Mapping of GATA-4 mutations causing cardiac congenital diseases in the Lebanese population |
| Bitar Moh'd | Helicobacter pylori and middle ear disease in children |
| Bitar Moh'd | Evaluation of nasal obstruction in infants and children: which tool is better |
| Bizri A/R | Utilization review of Amphotericin B at AUB-MC - A chart review |
| Bizri A/R | The practice of de-escalation therapy at the AUBMC |
| Bizri A/R | Epidemiology of Helicobacter pylori and hepatitis A virus among school students in Lebanon |
| Bizri A/R | Alopecia Areata- Treatment with DPCP |
| Bizri A/R | Review of ER records of patients with sore throat |
| Bizri A/R | Pharm D thesis on the efficacy of various antibodies in prophylaxix for transurethral resection of the prostate |
| Dakik, Habib | The "inspire" trial: a randomized prospective multicenter trial evaluation of the role of adenosine Tc-99m sestamibi single photon emission computed tomography for assessing risk and therapeutic outcomes in survivors of acute myocardial infraction |
| Dbaibo Ghassan | A prospective trial of influenza vaccine |
| El-Hajj-Fuleihan Ghada | Effect of topical steroids on bone metabolism |
| El-Hajj-Fuleihan Ghada | Hip fracture in a tertiary referral center, AUB-MC. Determinants & prognosis. |
| El-Hajj-Fuleihan Ghada | Effect of vitamin D replacement on musculoskeletal parameters in healthy adolescents. A randomized controlled trial. |
| El-Hajj-Fuleihan Ghada | Effect of long term antiepileptic drug therapy on bone mineral density and response to different doses of vitamin D: controlled therapeutic trial in ambulatory patients |
| El-Hajj-Fuleihan Ghada | Bone density in the Lebanese: clinical relevance and predictors of low bone mass (Renewal) |
| Hadi Usamah | Comparative genomic analysis of P. Aerations from nosocomial versus otitis externa community acquired infections |
| Hemadeh Ghassan | Control tower tracking of clinical performance PAR-01-04 small research grant |
| Jamaleddine Ghassan | Singulair in mild asthma |
| Jamaleddine Ghassan | Efficacy and safety of Drotrecogin alfa (activated) in adult patients with early stage severe sepsis |
| Kanj Suha | Human herpes virus-6 (HHV6) as a possible etiologic agent in idiopathic Bell's Palsy |
| Kanj Suha | Ertapenem treatment of intra abdominal infection, a randomized study |
| Kanj Suha | A prospective, multicenter, open-label, randomized, comparative study to evaluate, safety and tolerability of Ertapenem (MK-0826) versus Piperacillin-Tazobactam in the treatment of intra-abdominal infections in adults |
| Kanj Suha | Comparison of conventional cultures and 16S rRNA gene sequencing for detection of bacterial infection in patients with febrile neutropenia |
| Kaspar Hanna | Quantitative measurement of DNA in the maternal serum: clinical implications in the diagnosis of fetal aneuploidies and pregnancy-related complications |
| Khauli, Raja and Medawwar Walid | An open-label, non-comparative study of the efficiency and safety of cyclosporine dose reduction in de novo renal allograft recipients |
| Khogaly Mustafa | Use of nicotine replacement therapy |
| Khoury Brigette | Coping with infertility-induced stress: levels of depression and anxiety in Lebanese couples undergoing IVF treatment |
| Khoury Johnny | Modified anterior ciliary sclerotomy for reversing presbyopia |
| Major Stella | Determining the impact of a health awareness course on college students health related knowledge, attitudes and behaviors. |
| Major Stella (GebraneChristine) | The women and family life project |
| Mikati Moh'd | Effects of pediatric intractable epilepsy and of pediatric epilepsy surgery on quality of life: A prospective controlled study |
| Mikati Moh'd | Open naturalistic individual dose optimization trial assessing tolerability and efficacy of topiramate monotherapy in recently diagnosed patients with epilepsy who are treatment naïve or have failed one anti-epileptic drug treatment in monotherapy |
| Mikati Moh'd | A double-blind, placebo-controlled, add-on clinical trial of the safety, pharmacokinetics and efficacy of lamictal in pediatric age subjects (1-24 months) |
| Mikati Moh'd |
Protocol Amendment - Lamictal An open-label, uncontrolled long-term study to assess the safety of Lamictal in pediatric subjects who have previously taken part in study LAM20006 |
| Mroueh salman | A double blind, randomized, double dummy, multi-center study to evaluate and compare montelukast and inhaled fluticasone in the control of asthma for 6-14 year-olds with mild persistent asthma |
| Musharrafieh Umayya | Prevalence of antibodies against parvovirus B19 in pregnant women a tertiary care center in Lebanon |
| Nabulsi Mona | Vesicoureteral reflux detection in urinary tract infection: early versus late voiding cystourethrogram |
| Nabulsi Mona | A randomized controlled trial of single versus combination antipyretic treatment in febrile children |
| Nassar Nabil | Profile of bloodstream infections at the American university of Beirut Medical Center |
| Nuwayri-Salti Nuha | Prevalence of some specific HLA class II alleles identified by related microsatellites and relationship to phenotypes in Lebanese patients with IDDM and their association with specific parental HLA class II genes |
| Nuwayri-Salti Nuha | Temporal and spatial changes in eosinophil granulocyte number and type in human thymus glands that underwent natural and stress related involution |
| Saab Bassem | Intestinal parasites among presumably healthy Lebanese subjects |
| Saab Bassem | Sesame oil use in ameliorating cough in children: myth or reality |
| Saghir Naji | Randomized phase II-III study in first line hormonal treatment for metastatic breast cancer with Exemestane or Tamoxifen in postmenopausal patients |
| Saghir, Nagi | BCIRG 006: A multicenter phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab and with docetaxel and platinum salt and trastuzumab in the adjuvant treatment of node positive and high risk node negative adjuvant patients with operable breast cancer containing the Her-2-neu alteration |
| Salman Salah | The impact of topical steroid application on post inflammatory hyperpigmentation |
| Salti Ibrahim | A randomized open-label trial to asses the post-meal glucose control achieved with Starlix 120mg before 3 meals daily in practice-based setting |
| Samir Shehadi | Role of the corrugator supercillii in migraine |
| Seoud Muhieddine | Human papilloma virus: incidence and prevalence in cervical cancer over 17 years (Renewal in Sp02) |
| Seoud, Muhieddine | Concurrent chemotherapy with radiotherapy for advanced carcinoma of the cervix: a randomized controlled study comparing weekly taxi to weekly cisplatinum |
| Shamseddine Ali | A phase II clinical study of Docetaxel and Irinotecan in advanced non-small cell lung cancer |
| Shamseddine Ali | A clinical phase II study of cisplatinum and vinorelbine followed by docetaxel as first treatment in metastatic breast cancer (MBC) |
| Shamseddine Ali | A randomized phase III study comparing concomitant Docetaxel Plus Gemcitabine to sequential therapy of Docetaxel followed by Gemcitabine in anthracycline- pretreated metastatic or locally recurrent breast cancer patients |
| Sharara Alaa | Efficacy of 5 or 7 day Gatifloxacin-based therapy for the treatment of Helicobacter pylori |
| Sharara Alaa | A prospective trial of single-dose Cefotaxime as perioperative prophylaxis in uncomplicated acute cholecystitis |
| Sharara Alaa | Distribution of Hepatitis B and Hepatitis C genotypes in Lebanese patients with chronic Hepatitis B and chronic Hepatitis C respectively |
| Soweid, Asaad | The efficacy of rabeprazole-based triple therapy regimen for the eradication of Helicobacter pylori |
| Usta Ihab | Chromosomal and pathologic placental anomalies of ART pregnancies correlation with fetal karyotype and neonatal outcome |
| Yamout Bassem | Open label, multicenter, randomized trial to evaluate the development of polycystic ovary syndrome (PCOS) in female subjects with newly diagnosed epilepsy initiating anti-epileptic drug treatment on either lamotrigine or valproate monotherapy |
| Yunis Khaled | National collaborative perinatal neonatal data base (Renewal) |
| Yunis Khaled | Patterns of neonatal infant in greater Beirut |
| Pre-clinical/ Basic Science Research | |
| Principal Investigator | Title of Research Proposal |
| Al-Amin Hassan | Neurodevelopmental perspectives of the neonatal ventral hippocampus lesion as an animal model of schizophrenia |
| Barada Kassem | Effect of proinflammatory and antiinflammatory cytokines on intestinal amino acid, glucose and water absorption in the rat |
| Barada Kassem | Effect of experimental diabetes on taurine transport in the rat intestine |
| Bazarbachi Ali | The mechanism of action and development of novel therapies for HTLV-I associated adult T-cell leukemia/lymphoma |
| Bikhazi Anwar | Assessment of insulin receptor alteration (s) in myocardial infarcted rat hearts |
| Bikhazi Anwar | pH-Regulated uptake of Gly-sar across jejunum of diabetic rats |
| Bikhazi Anwar | Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction and the effect of ETA and ETB blockade |
| Bitar Fadi | Role of NF-kappa B in myocardial proliferation in a rat model of chronic hypoxia mimicking cyanotic heart disease |
| Bitar Fadi | Adaptive molecular mechanisms of cardiac growth in the chronically hypoxia rat heart: roles of sphingolipid metabolites and angiogenesis |
| BouKhalil Pierre | Acute lung injury and end organ damage in mechanically ventilated rats |
| Dbaibo Ghassan | Regulation of the ceramide pathway by the adenoviral E1A gene |
| Dbaibo Ghassan | Regulation of protein kinase C θ by ceramide |
| Dbaibo Ghassan | Regulation of cellular ceramide levels by p53-activated pathways in the apoptotic stress response |
| Habib Aida | Transcriptional regulation of cyclooxygenase-2 by stains: analysis of the promoter activity and transcriptional elements involved |
| Habib Aida & Badr Kamal | Cellular regulations of cyclooxygenase II in human leukocytes and vascular endothelial cells by statins |
| Homaidan Fadia | Regulation of intestinal epithelial cell function in inflammation |
| Homaidan Fadia | Regulation of intestinal epithelial cell function by soluble mediators and cell-cell communication |
| Khattar Mirielle | Development and validation of a high throughput assay for rapid diagnosis of human and animal brucellosis using real-time PCR |
| Matar Ghassan | Sequence analysis, transcription and expression levels of TonB Gene in H. influenza and H. parainfluenza isolated from tonsillar sites of patients undergoing tonsillectomy and adenoidectomy |
| Matar Ghassan | Regulation of tonB and other virulent genes among diarrheagenic E. coli by changes in iron availability |
| Matar Ghassan | In vitro and in vivo assessment of agents with an inhibitory effect of the expression of shiga-like toxin and intimin in Escherichia Coli O157:H7 |
| Mattar Ghassan | Correlation between levels of Pseudomonas aeruginosa exotoxin A mRNA transcripts and protein and severity of symptoms in patients with otitis externa |
| Mikati Moh'd | Is there activation of the programmed cell death cascade in experimental chronic temporal lobe epilepsy? |
| Mikati Moh'd | The mechanisms of ceramide generation following kainic acid-induced status epilepticus |
| Mikati Moh'd | Mechanisms of neuronal injury caused by chronic hypoxia in the developing brain |
| Mikati Moh'd | Potential role of ceramide in status epilepticus related brain injury- Renewal: Mechanisms of programmed cell death after status epilepticus |
| Mourad Fadi | Effect of ulcerative colitis on water and nutrient absorption across rat jejunum |
| Mourad Fadi | Inhibitory effect of intestinal alanine on jejunal alanine absorption: role of the neuroendocrine system |
| Mroueh Salman | Nuclear factor kappa-B and ceramide in lung epithelial cells exposed to hyperoxia |
| Nassar Camille | Neural control of water and nutrient absorption in the small intestine |
| Nasser, Michel | Reversibility of monocrotaline-induced pulmonary vascular injury and hypertension and right ventricular remodeling in the rat. |
| Nuwayri Salti Nuha | Development of a vaccine against Leishmania organisms: Trial I in a murine model |
| Nuwayri-Salti Nuha | Prevalent environmental factors which determine the species phlebotomine sandflies and related biotope in Leishmaniasis Focus in Lebanon |
| Saade` Nayef | Physiology and pharmacology of pain related behavior produced by various challenges to the peripheral and central nervous system (PNS and CNS) |
| Sabban Marwan | Angiogenesis and heterocellular communication in leukemia: Implications for invasion and metastasis using ATL as a model |
| Sabra Ramzi | Influence of Thymulin on acute liver failure induced by galactosamine/endotoxin injection in rats |
| Sabra Ramzi | Studies on the participation of cGMP specific phosphodiesterase (PDE5) in vascular relaxation |
| Sabra Ramzi | Role of changes in PDE 5 activity in the vascular and renal complications of cirrhosis |
| Saghieh Said | Impact of Zoledronic acid on distraction osteogenesis |
| Sharara Ala' | Role of inducible nitric oxide synthase and nitric oxide in interferon and interferon/arsenic mediated apoptosis in HTLV-I transformed cells and HTLV-I negative activated T cells |
| Usta Julnar | Sphingolipid metabolism in mitochondria. Direct effect of sphingosine and ceramide on the mitochondrial respiratory chain complexes and on cytochrome-c release |
| Usta Julnar | Quantitation of sphingosine 1-phosphate- pilot study |
| Usta Julnar | The biological effect of urea-C6 ceramide: an inhibitor of mitochondria ceramidase |
| Zahed Layla | The molecular basis of albinism in Lebanon |