CHARMm: Comprehensive force field and program for energy calculations. Includes extensive parameter library.

Ludi: de novo design software.

Binding Site Analysis: Software to locate a proteins binding site and then use sequence family information to indentify characteristics that determine function. Requires Insight II.

MCSS: Characterization and analysis of potential ligand binding sites. Requires Insight II, CHARMm.

Sketcher : used to draw molecules in 2D and automatically convert them to 3D models.

2- Rational and Combinatorial Drug Design 

C2.Visualizer:  Comprehensive chemical computing environment.  Required core product.

C2.Minimizer: Performs energy minimization of molecular and periodic structures. 

C2.OFF: Open force field includes library of standard materials force fields. Includes Dreiding, Universal, and other force fields.

C2.MMFF: Provides Merck Molecular Modeling Force Field for use with Drug Discovery applications.

C2.Conformers: Provides conformational search algorithms and analysis tools for molecular structures. 

C2.Alignment: Molecular similarity and superpositioning methods.

C2.FieldFit: Performs molecular alignment based on steric and electrostatic fields as well as alignments on moments of inertia and electrostatic moments.

C2.DB Access: Access to ISIS and Catalyst database searching programs.

C2.Force Field Editor: Provides force field customization tools.

C2.QSAR+: Comprehensive toolkit with molecular descriptors and statistical techniques for QSAR applications.

C2.Descriptor+: Additional QSAR/QSPR descriptors for materials and life science applications. 

C2.Genetic Algorithims: Genetic function approximation applied to QSAR. 

C2.MFA: Molecular field analysis for 3D QSAR.

C2.Receptor: Toolkit for creation and evaluation of pseudo-receptor models.