Dr. Hassan Khachfe earned a B.S. degree in Physics from the American University, an M.S. in Polymer Physics from Wichita State University, and a Ph.D. in Biophysics from Boston University. Dr. Khachfe worked as a research fellow at the Northeastern University and the Center for Advanced Biomedical Research in Boston, before he was recruited to join the AUB medical facultyHis interests include the structural determination and characterization of macromolecular assemblies using biophysical and computational techniques. Dr. Khachfe's projects focus on the molecular details of the structure, stability and dynamic properties of the plasma apolipoproteins, particularly Apo B100 of the low density lipoprotein (LDL). This information is vital to an understanding of lipid interactions, lipoprotein cell surface interactions, receptor-mediated lipoprotein uptake, and lipoprotein inter-conversions that form the basis of lipid transport and metabolism. A detailed understanding of apolipoprotein structural stability and adaptability is vital to further progress in understanding lipoprotein structure and function. The precise molecular mechanisms of this unique structural adaptability remain unclear. They are the focus of a major component of Dr. Khachfe's research, and are being investigated using biophysical techniques as well as computational approaches. The latter employs some state-of-the-art computer hardware and software housed by the Bioinformatics and Computational Sciences Unit.